Dr. Andreas Bögehold (2005 - 2008)

++49 - 551 - 201 1336 (Lab), 201 1248 (Office) e-mail

• Kinetics of amyloid fibril formation of different protein systems
• Modelling the process of amyloid fibril formation
• Analytics of water soluble polymers

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Depletion of monomer concentration during the formation of amyloid fibrils from the amyloid-(beta)(1-40) peptide. The graph represents the peak intensities for the monomer acquired by liquid beam desorption mass spectrometry.

PCGG activities

Cooperation(s):

• Mukrasch, Mandelkow, Zweckstetter - Griesinger group (Aggregation of τ-Protein)
• Cho, Zweckstetter - Griesinger group (Aggregation of α-Synuclein)
• Niemeyer - group (Analysis of biologically relevant polymers)
• Herzog group (Static light scattering experiments)
• Heim - Jovin group (AFM-Images of insulin fibrils)
• Schollmeyer, Thieme - group (X-ray-microscopy of insulin-fibrils)
• Vöhringer-Martinez - Abel group (MD Simulations of the desorption process)

• Project Week in the Grubmüller Group: Molecular Dynamic Simulations of Insulin at Acidic Conditions

• ♦ J. Haas, E. Vöhringer-Martinez, A. Bögehold, D. Matthes, U. Hensen, A. Pelah, B. Abel, H. Grubmüller, Primary Steps of pH-dependent Insulin Aggregation Kinetics Are Governed by Conformational Flexibility, ChemBioChem 2009, 10, 1816-1822.
• ♦ A. Charvat, F. Gessler, J. Niemeyer, A. Boegehold, B. Abel, Rapid quantitative detection of bovine serum albumin in blood serum with seeded liquid beam desorption mass spectrometry, Anal. Lett. 2006, 39(10), 2191-2203.
• ♦ A. Charvat, A. Bögehold, B. Abel, Time-resolved micro liquid desorption mass spectrometry: Mechanism, features, and kinetic applications (Review), Aust. J. Chem. 2006, 59, 81-103.

• Poster: April 07 2008 Exploring the kinetics of protein aggregation and amyloid fibril formation (11th Workshop)
• Talk: April 07 2008 Exploring the kinetics of protein aggregation and amyloid fibril formation (11th Workshop)
• Organization: Sept 18 2007 Chair at the 10th Workshop, Orsay
• Poster: Sept 17 2007 Investigation of biomolecular aggregation and polymers by liquid beam desorption mass spectrometry (10th Workshop)
• Talk: Mar 19 2007 Investigation of biomolecular aggregation and polymers by liquid beam desorption mass spectrometry (9th Workshop)
• Poster: Mar 21 2006 Probing macromolecular transformations by quantitative liquid beam desorption mass spectrometry (Review Colloquium)
• Organization: Mar 08 2006 Host student of C. Desfrancois (Seventh Workshop 2006
  Spectroscopy and Dynamics of Molecular Coils and Aggregates (Göttingen - Paris))
• Poster: Mar 08 2006 Probing macromolecular transformations by quantitative liquid beam desorption mass spectrometry (Seventh Workshop 2006
  Spectroscopy and Dynamics of Molecular Coils and Aggregates (Göttingen - Paris))
• Talk: Jun 01 2005 Time resolved liquid beam desorption mass spectrometry: From high throughput analysis to biomolecule kinetics (Seminar SS 2005)
• Poster: April 06 2005 Online monitoring of biopolymer transformations via quantitative liquid beam desorption mass spectrometry (Fifth Workshop = 91st Bunsen Colloquium 2005)