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Prof. Dr. Bert L. de GrootSupervisor
Students (including co-supervision): Dirk Matthes
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 ++49 - 551 - 201 2308
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 homepage (http://www.mpibpc.mpg.de/groups/de_groot/bgroot.html)
Max-Planck-Institut für Biophysikalische Chemie
Computational biomolecular dynamics group
Faßberg 11
37077 Göttingen
Germany |
Research Interests
Protein structure-dynamics-function relationships, studied by computer simulations
Curriculum Vitae
1971 Born in Emmen, NL
1983 - 1989 Ubbo Emmius Lyceum (Stadskanaal, the Netherlands)
1989 - 1994 studied Chemistry at the university of Groningen, the Netherlands. Specialisation: Biophysical chemistry
1994 - 1998 PhD student a the the university of Groningen, the Netherlands, the department of biophysical chemistry
Promotor: prof. H.J.C. Berendsen. Subject: Native state protein dynamics studied by a variety of computer simulation techniques
1998 - 2003 Postdoctoral fellow in the theoretical molecular biophysics group headed by Dr. Helmut Grubmüller at the Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany;
Subject: Structure and function of aquaporins
2003 - present Head of the computational biomolecular dynamics group, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
PCGG activities
Ongoing and Planned Research Group Interaction(s) within the Graduate School
Publications: (♦ - published,
♦ - in press, ♦ - submitted) - ♦ D. Matthes, B. L. de Groot, Secondary structure propensities in peptide folding simulations: A
systematic comparison of molecular mechanics interaction schemes., Biophys. J. 2009, 97, 599-608.
- ♦ U. Zachariae, R. Schneider, P. Velisetty, A. Lange, D. Seeliger, S. J. Wacker, Y. Karimi-Nejad, G. Vriend, S. Becker, O. Pongs, M. Baldus, B. L. de Groot, The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type activation, Structure 2008, 16, 747-754.
- ♦ O. F. Lange, H. Grubmüller, B. L. de Groot, Molecular Dynamics Simulations of Protein G Challenge NMR-Derived Correlated Backbone Motions, Angew. Chem. Int. Ed. 2005, 44, 3394-3399.
- ♦ H. Heise, S. Luca, B. de Groot, H. Grubmüller, M. Baldus, Probing conformational disorder in neurotensin by two-dimensional solid-state NMR and comparison to molecular dynamics simulations, Biophysical Journal 2005, 89(3), 2113-2120.
- ♦ B. L. de Groot, T. Frigato, V. Helms, H. Grubmüller, The mechanism of proton exclusion in the aquaporin-1 water channel, J. Mol. Biol. 2003, 333, 279-293.
- ♦ B. L. de Groot, D. P. Tieleman, P. Pohl, H. Grubmüller, Water permeation through gramicidin A: desformylation and the double helix; a molecular dynamics study, Biophys. J. 2002, 82, 2934-2942.
Events:- Talk: Jan 26 2011 TBA (Introductory Lecture WS 2010/2011 - Biomolecular Aggregates)
- Talk: Oct 22 2008 Aggregation in silico (Introductory Lecture WS 2008/2009 - Biomolecular Aggregates)
- Talk: May 23 2007 Fundamentals of Molecular Dynamics Simulations (Introductory Lecture SS 2007 - Molecular Models)
- Talk: Feb 01 2006 Biomolecular dynamics: from peptide folding to membrane transport (Seminar WS 2005/2006)
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