Dr. Adam Lange

+49 - 551 - 201 2214 e-mail homepage (http://www.mpibpc.mpg.de/english/research/ags/lange/index.html) Max-Planck-Institut für Biophysikalische Chemie Am Faßberg 11 37077 Göttingen Germany

• solid-state NMR
• method development and biophysical applications
• amyloids
• membrane proteins

PCGG activities

Publications: (♦ - published, ♦ - in press, ♦ - submitted)

• ♦ R. Schneider, M. Etzkorn, K. Giller, V. Daebel, J. Eisfeld, M. Zweckstetter, C. Griesinger, S. Becker, A. Lange, The Native Conformation of the Human VDAC1 N Terminus, Angew Chem Int Ed Engl 2010, 49, 1882-1885.
• ♦ A. Sachse, S. Demeshko, S. Dechert, V. Daebel, A. Lange, F. Meyer, Highly preorganized pyrazolate-bridged palladium(II) and nickel(II) complexes in bimetallic norbornene polymerization, Dalton Trans 2010, 39, 3903-3914.
• ♦ R. Schneider, K. Seidel, M. Etzkorn, A. Lange, S. Becker, M. Baldus, Probing molecular motion by double-quantum (¹³C,¹³C) solid-state NMR spectroscopy: Application to ubiquitin, J. Am. Chem. Soc. 2010, 132, 223-233.
• ♦ H.-Y. Kim, M.-K. Cho, A. Kumar, E. Maier, C. Siebenhaar, S. Becker, C. Fernandez, H. Lashuel, R. Benz, A. Lange, M.Zweckstetter, Structural properties of pore-forming oligomers of alpha-synuclein, J. Am. Chem. Soc. 2009, 131, 17482-17489.
• ♦ U. Hensen, H. Grubmueller, O. Lange, Adaptive anisotropic kernels for nonparametric estimation of absolute configurational entropies in high-dimensional configuration spaces, Physical Review E 2009, 80 (1), 011913.
• ♦ O. Pongs, C. Ader, R. Schneider, S. Hornig, P. Velisetty, E. M. Wilson, A. Lange, K. Giller, M. F. Martin-Eauclaire, D. Trauner, S. Becker, M. Baldus, A structural link between potassium channel gating and drug binding, FEBS J 2008, 275, 174-174.
• ♦ R. Schneider, C. Ader, A. Lange, K. Giller, S. Hornig, O. Pongs, S. Becker, M. Baldus, Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers, J. Amer. Chem. Soc. 2008, 130, 7427-7435.
• ♦ C. Ader*, R. Schneider*, S. Hornig, P. Velisetty, E. M. Wilson, A. Lange, K. Giller, I. Ohmert, M. F. Martin-Eauclaire, D. Trauner, S. Becker, O. Pongs, M. Baldus, A Structural Link between Inactivation and Block of a K+ channel, Nature Struct. Mol. Biol. 2008, 15, 605-612. ( * equally contributing authors)
• ♦ J. Korukottu, R. Schneider, A. Lange, V. Vijayan, O. Pongs, S. Becker, M. Baldus, M. Zweckstetter, High-resolution 3D structure determination of kaliotoxin by solid-state NMR spectroscopy, PLoS ONE 2008, 3 (6), e2359.
• ♦ U. Zachariae, R. Schneider, P. Velisetty, A. Lange, D. Seeliger, S. J. Wacker, Y. Karimi-Nejad, G. Vriend, S. Becker, O. Pongs, M. Baldus, B. L. de Groot, The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type activation, Structure 2008, 16, 747-754.
• ♦ A. Lange, K. Giller, S. Hornig, M. F. Martin-Eauclaire, O. Pongs, S. Becker, M. Baldus, Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR, Nature 2006, 440, 959-962.
• ♦ A. Böckmann, A. Lange, A. Galinier, S. Luca, N. Giraud, M. Juy, H. Heise, R. Montserret, F. Penin, M. Baldus, Solid-state NMR sequential resonance assignments and conformational analysis of the 2 x 10.4 kDa dimeric form of the Bacillus subtilis protein Crh, J Biomol NMR 2003, 27, 323-339.

• Talk: Jan 12 2011 Biomolecular Aggregrates: A Solid-State NMR View (Introductory Lecture WS 2010/2011 - Biomolecular Aggregates)
• Talk: Jan 14 2009 Solid state NMR: Principles and Biophysical Applications (Introductory Lecture WS 2008/2009 - Biomolecular Aggregates)